There is a need for health promotion interventions for LGBTQ youth that can reduce critical health gaps that LGBTQ youth experience. Schools are an important environment for youth, and a key place where public health professionals, partnering with school staff, can support effective health promotion strategies. Indeed, some of the best strategies for promoting youth health are those undertaken by educators in schools that also contribute to improvements in learning. In the following report, we identified and evaluated research evidence for school-based interventions to improve outcomes for LGBTQ youth. We examined the relevance of the research for schools in Canada, and applied the outcomes evidence to a “typical” BC secondary school of 1000 students as a practical example. We also weighed the potential benefits of different school interventions compared to some of the estimated costs of the health outcomes they address. Our goal was to provide evidence-informed guidance on how schools and their public health partners might work together to narrow the health gap for LGBTQ youth.