Peer Reviewed Journals

Költő A, Young H, Burke L, Moreau N, Cosma A, Magnusson J, Windlin B, Reis M, Saewyc EM, Godeau E, Gabhainn SN. (2018) Love and Dating Patterns for Same‐ and Both‐Gender Attracted Adolescents Across Europe. Journal of Research on Adolescence.

Abstract Sexual orientation is a multidimensional phenomenon, which includes identity, behavior, and attraction. The attraction component, however, is less studied than the other two. In this article, we present the development of a two‐item measure to identify adolescents who prefer same‐ and both‐gender partners for love and dating. The questions were administered to nationally representative […]

Watson RJ, VanKim NA, Rose HA, Porta CM, Gahagan J & Eisenberg ME. (2018) Unhealthy weight control behaviors among youth: Sex of sexual partner is linked to important differences. Eating Disorders.

Abstract Unhealthy weight control behaviors (UWCBs) have been decreasing for most youth over time, yet little is known whether these behaviors have changed for sexual minority (e.g., non-heterosexual) youth. This is important because many studies have found that sexual minorities report some of the highest rates of UWCBs. To determine whether or not these behaviors […]

Watson RJ, Peter T, McKay T, Edkins T, and Saewyc E (2018). Evidence of changing patterns in mental health and depressive symptoms for sexual minority adolescents, Journal of Gay & Lesbian Mental Health

Abstract Depression, sadness, low self-esteem, and self-harm affect a substantial number of young people in North America. However, the prevalence of these symptoms has been found to be consistently higher for sexual minority (i.e., lesbian, gay, bisexual) populations. In this study, we traced the trends and disparities in mental health, including self-harm, forgone mental health […]

Watson RJ, Lewis NM, Fish JN, Goodenow C. Sexual minority youth continue to smoke cigarettes earlier and more often than heterosexuals: Findings from population-based data. Drug and Alcohol Dependence, 184: 64–70. 2018

Abstract Background An established body of research documents that sexual minority (i.e., lesbian, gay, and bisexual) populations are at higher risk for several adverse health behaviors and outcomes compared to their heterosexual counterparts. Smoking is one behavior where the gap is especially large, particularly among youth. Researchers have increasingly drawn attention to contextual determinants of […]

Clark BA, Veale JF, Townsend M, Frohard-Dourlent H, and Saewyc E. Non-binary youth: Access to gender-affirming primary health care. International Journal of Transgenderism, 2018

Abstract Background: Transgender (trans) youth who identify outside the gender binary are a growing subpopulation. In this article, we document differences in access to gender-affirming health care between binary and non-binary identified trans youth and explore ways of meeting the health needs of non-binary youth within primary care settings. Methods: The Canadian Trans Youth Health Survey is […]

Veale JF, Peter T, Travers R, and Saewyc EM. (2017) Enacted Stigma, Mental Health, and Protective Factors Among Transgender Youth in Canada. Transgender Health. December 2017, 2(1): 207-216.

Abstract Purpose: We aimed to assess the Minority Stress Model which proposes that the stress of experiencing stigma leads to adverse mental health outcomes, but social supports (e.g., school and family connectedness) will reduce this negative effect. Methods: We measured stigma-related experiences, social supports, and mental health (self-injury, suicide, depression, and anxiety) among a sample of 923 […]

Doull M, Wolowic J, Saewyc E, Rosario M, Prescot T, Ybarra M. (2017) Why girls choose not to use barriers to prevent STI transmission during female-to-female sex. Journal of Adolescent Health.

Abstract Purpose Using data from a national qualitative study of lesbian, bisexual, and other sexual minority adolescent girls in the U.S., this study examined their awareness of the risk of sexually transmitted infection (STI) and opportunities for barrier use. Methods Online asynchronous focus groups were conducted with lesbian and bisexual (LB) girls ages 14–18 years. […]

Moynihan M, Mitchell K, Pitcher C, Havaei F, Ferguson M, Saewyc E. (2018). A systematic review of the state of the literature on sexually exploited boys internationally. Child Abuse & Neglect, 76, 440–451.

This systematic review assessed the current state of the literature on sexually exploited boys internationally. We aimed to describe what is known about sexual exploitation of boys, identify gaps in the literature, provide implications for practice, and make recommendations for future research. Multiple database searches were conducted using a combination of controlled vocabulary and keywords […]

Beth A Clark, Jaimie F Veale, Devon Greyson, Elizabeth Saewyc. Primary care access and foregone care: a survey of transgender adolescents and young adults. Family Practice (2017)

Transgender adolescents and young adults are at increased risk for many negative health outcomes, including depression, anxiety and suicide. Research has documented that transgender adults and cisgender (non-transgender) adolescents may experience barriers to health care, and that foregone care is associated with poorer physical and mental health outcomes. Barriers to medical care experienced by transgender […]

Marla E. Eisenberg, Christopher J. Mehus, Elizabeth M. Saewyc, Heather L. Corliss, Amy L. Gower, Richard Sullivan & Carolyn M. Porta. Helping Young People Stay Afloat: A Qualitative Study of Community Resources and Supports for LGBTQ Adolescents in the United States and Canada. Journal of Homosexuality (2017).

LGBTQ youth are at increased risk of poor health outcomes. This qualitative study gathered data from LGBTQ adolescents regarding their communities and describes the resources they draw on for support. We conducted 66 go-along interviews with diverse LGBTQ adolescents (mean age = 16.6) in Minnesota, Massachusetts, and British Columbia in 2014–2015, in which interviewers accompanied participants in […]

Frohard-Dourlent, H, Dobson S, Clark B, Doull M, Saewyc E. “I would have preferred more options”: accounting for non-binary youth in health research. Nursing Inquiry. 24 (2017): 1-9.

As a research team focused on vulnerable youth, we increasingly need to find ways to acknowledge non-binary genders in health research. Youth have become more vocal about expanding notions of gender beyond traditional categories of boy/man and girl/woman. Integrating non-binary identities into established research processes is a complex undertaking in a culture that often assumes […]

Porta C, Gower A, Mehus C, Yu X, Saewyc E, Eisenberg, M (2017). “Kicked out”: LGBTQ youths’ bathroom experiences and preferences. Journal of Adolescence. 56 (2017): 107-112.

Abstract Attention toward who can use which gender binary, multi-stall bathroom has brought to the forefront, once again, the ways in which youth are supported or marginalized. No study has documented sexual and gender minority youths’ experiences with and perspectives about bathrooms. We collected qualitative data in 2014–2015. Participants were 25 lesbian, gay, bisexual, transgender, […]

Marion Doull, Ryan J. Watson, Annie Smith, Yuko Homma, Elizabeth Saewyc, Are we leveling the playing field? Trends and disparities in sports participation among sexual minority youth in Canada, Journal of Sport and Health Science (2016), 1-9.

Sports participation and physical fitness are widely beneficial for young people, yet activity levels among young people are declining. Despite growing popular media attention on the participation of sexual minority (e.g., lesbian, gay, and bisexual) youth in sports and various campaigns to improve the often homophobic climate of sports, there is limited evidence that sexual […]

Adjei, J, Saewyc E (2017). Boys are not exempt: Sexual exploitation of adolescents in sub-Saharan Africa. Child Abuse & Neglect. 65 (2017): 14-23.

Research on youth sexual exploitation in Africa has largely neglected the experiences of exploited boys. To date, much of the research in sub-Saharan Africa continues to consider boys mainly as exploiters but not as exploited. Using the only publicly available population-based surveys from the National Survey of Adolescents, conducted in four sub-Saharan African countries — […]

Wolowic J, Heston L, Saewyc E, Porta C, Eisenberg M (2016). Chasing the rainbow: lesbian, gay, bisexual, transgender and queer youth and pride semiotics. Culture, Health and Sexuality. 2016 Nov 10:1-15

While the pride rainbow has been part of political and social intervention for decades, few have researched how lesbian, gay, bisexual, transgender and queer young people perceive and use the symbol. How do lesbian, gay, bisexual, transgender and queer youth who experience greater feelings of isolation and discrimination than heterosexual youth recognise and deploy the […]

Creighton G*, MacMillan E*, Oliffe J, Saewyc E. (2015). Living for the moment: Men consider risk practices following the death of a friend.Sociology of Health and Illness. 37(3): 355-369.

The primary cause of death for men under the age of 30 is unintentional injury and, despite health-promotion efforts and programme interventions, male injury and death rates have not decreased in recent years. Drawing on 22 interviews from a study of men, risk and grief, we describe how a risk-related tragedy shaped the participants’ understandings […]

Mitchell K*, Roberts A, Gilbert M, Homma Y*, Warf C, Daly K*, Saewyc, E. (2015). Improving the accuracy of Chlamydia trachomatis incidence rate estimates among adolescents in Canada. Canadian Journal of Human Sexuality. 24(1): 12-18.

In this study, the authors assessed the impact of adjusting for sexual activity on population-based chlamydia incidence and screening rates among adolescents in the province of British Columbia (BC), Canada. They estimated the proportion of adolescent males (15 years-18 years) and females (14 years-18 years) who had ever had sexual intercourse using data from a […]

Blander E*, Saewyc E. (2015). Adolescent reactions to icon-driven response modes in a tablet-based health screening tool. Computing, Informatics, & Nursing. 33(5): 181-8.

Increasingly popular touch-screen electronic tablets offer clinics a new medium for collecting adolescent health screening data in the waiting area before visits, but there has been limited evaluation of interactive response modes. This study investigated the clarity, comprehensibility, and utility of icon-driven and gestural response functions employed in one such screening tool, TickiT. We conducted […]

Edinburgh LD, Harpin S, Pape-Blabolil J, Saewyc E. (2015). Assessing exploitation experiences of adolescent girls and boys seen at a Child Advocacy Center. Child Abuse & Neglect. 46: 47-59.

The primary aim of this study was to describe the abuse experiences of sexually exploited runaway adolescents seen at a Child Advocacy Center (N = 62). We also sought to identify risk behaviors, attributes of resiliency, laboratory results for sexually transmitted infection (STI) screens, and genital injuries from colposcopic exams. We used retrospective mixed-methods with in-depth forensic […]

Moynihan M*, Saewyc E, Whitehouse S, Paone M, McPherson G. (2015). Assessing readiness for transition from paediatric to adult health care: Revision and psychometric evaluation of the “Am I ON TRAC for Adult Care”. Journal of Advanced Nursing. 71(6): 1324-1355.

Aim To refine and psychometrically test the Am I ON TRAC for Adult Care questionnaire. Background Inadequate transition to adult care for adolescents with special healthcare needs has been associated with greater risk of treatment non-adherence, lack of medical follow-up, increased morbidity and mortality. Presently, there are no well-validated measures assessing adolescents’ readiness to transition […]

Al Makadma A, Moynihan M*, Dobson S, Saewyc E. (2015). Tobacco use among adolescents in Riyadh, Saudi Arabia. International Journal of Adolescent Medicine and Health. 27(3): 357-360.

Initiation of smoking behavior during adolescence is associated with negative health outcomes. Understanding initiation of smoking behavior in adolescents in relation to other behavioral, health, and environmental factors is essential for effective behavioral modification. The aim of this study was to describe tobacco use behaviors among adolescents in Riyadh, Saudi Arabia, and related demographic and […]

Jenkins E*, Johnson J, Bungay V, Kothari A, & Saewyc E. (2015). Divided and disconnected – an examination of young people’s experiences with emotional distress within the context of their everyday lives. Health & Place. 35: 105-112.

This paper is based on a qualitative study conducted in a rural community in British Columbia, Canada. Ethnographic methods were used to: (1) to bring youth voice to the literature on emotional distress; and (2) to capture the ways in which context shapes young peoples’ experiences of emotional distress within their everyday lives. Our findings […]

Homma Y*, Wong S, Zumbo B, Saewyc E.(2015). Ethnic identity and sexual initiation among East Asian youth in Canada.Journal of Immigrant and Minority Health. 17(5): 1580-1584.

Despite the large number of East Asian youth in Canada, little is known about their health and risk behaviors. We examined the relationship between ethnic identity and sexual initiation among East Asians. This secondary analysis of a population-based survey selected 4,311 students in 7-12th grades who described themselves as East Asian (e.g., Chinese, Japanese, Korean). […]

Creighton G*, Matthews J, Oliffe J, Saewyc E. (2016). “Dulling the edges”: Young men’s use of alcohol to deal with grief following the death of a male friend. Health Education & Behavior. 43(1): 54-60.

The death of a male friend can be challenging for men because expressions of grief can be governed and restrained by dominant ideals of masculinity. It is common for young men to engage in health risk practices, such as alcohol overuse, to deal with feelings of sadness. This qualitative study investigated the ways that young […]

Reorienting risk to resilience: street-involved youth perspectives on preventing the transition to injection drug use

Kira Tozer1, Despina Tzemis1, Ashraf Amlani1, Larissa Coser2, Darlene Taylor13, Natasha Van Borek1, Elizabeth Saewyc4 and Jane A. Buxton Background The Youth Injection Prevention (YIP) project aimed to identify factors associated with the prevention of transitioning to injection drug use (IDU) among street-involved youth (youth who had spent at least 3 consecutive nights without a […]

Peter, T. & Taylor, C. (2014). Buried above ground: A university-based study of prevalence and risk/protective factors for suicidality among sexual minority youth. Journal of LGBT Youth, 11(2), 125-149

This study examined differences in suicidal behavior between lesbian, gay, bisexual, transgender, and queer/questioning (LGBTQ) and non-LGBTQ university students as well as investigated the importance of risk and protective factors in the prediction of suicidality between these two groups. A total of 1,205 university students participated in the survey. Findings show, compared to non-LGBTQ respondents, […]

Sathi P, Kalyan S, Hitchcock CL, Pudek M, Prior JC (2013) Progesterone Therapy increases Free Thyroxine Levels- data from a randomized placebo-controlled 12-week hot flush trial. Clinical Endocrinology, [Dec 17 2012 Epub ahead of print].

Thyroid hormones and progesterone both influence core temperature, metabolism and are crucial during pregnancy. Our objective was to discover whether progesterone therapy caused changes in thyroid physiology compared with placebo. Post hoc analysis from a randomized (1:1) placebo-controlled 12-week trial of oral micronized progesterone (Progesterone, 300 mg/d at bedtime) for hot flushes (vasomotor symptoms, VMS) […]

Devries K, Free C, Saewyc E. (2012). “I like to think I’m a pretty safe guy but sometimes a 40-pounder will change that”: A mixed methods study of substance use and sexual risk among Aboriginal young people. Journal of Aboriginal Health, 9(1), 41-51.

We conducted a mixed methods study to explore links between substance use and sexual risk among Aboriginal young people in British Columbia, Canada. Individual in-depth interviews were conducted in 2004–2005 with 30 young people ages 15–19; we present a descriptive thematic analysis. Data from a 2003 provincially representative survey that included 2,467 Aboriginal young people […]

Macneil JA, Adachi JD, Goltzman D, Josse RG, Kovacs CS, Prior JC, Olszynski W, Davison KS, Kaiser SM; the CaMos Research Group (2012) Predicting fracture using 2D finite element modeling. Medical Engineering & Physics, 34(4):478-84.

A decrease in bone density at the hip or spine has been shown to increase the risk of fracture. A limitation of the bone mineral density (BMD) measurement is that it provides only a measure of a bone sample’s average density when projected onto a 2D surface. Effectively, what determines bone fracture is whether an […]

Lix LM, Azimaee M, Osman BA, Caetano P, Morin S, Metge C, Goltzman D, Kreiger N, Prior J, Leslie WD. (2012) Osteoporosis-related fracture case definitions for population-based administrative data. BMC Public Health, 12:301.

Population-based administrative data have been used to study osteoporosis-related fracture risk factors and outcomes, but there has been limited research about the validity of these data for ascertaining fracture cases. The objectives of this study were to: (a) compare fracture incidence estimates from administrative data with estimates from population-based clinically-validated data, and (b) test for […]

Langsetmo L, Hitchcock CL, Kingwell EJ, Davison KS, Berger C, Forsmo S, Zhou W, Kreiger N, Prior JC; CaMos Research Group.(2012) Physical activity, body mass index and bone mineral density-associations in a prospective population-based cohort of women and men: the Canadian Multicentre Osteoporosis Study (CaMos). Bone, 50(1):401-8.

Physical activity (PA) is an important modifiable risk factor for both bone mineral density (BMD) and body mass index (BMI). However, BMI is itself strongly predictive of BMD. Our aim was to determine the association between PA and BMD, with consideration of BMI as a potential mediating factor. The Canadian Multicentre Osteoporosis Study (CaMos) is […]

Berger C, Greene-Finestone LS, Langsetmo L, Kreiger N, Joseph L, Kovacs CS, Richards JB, Hidiroglou N, Sarafin K, Davison KS, Adachi JD, Brown J, Hanley DA, Prior JC, Goltzman D; the CaMos Research Group (2012) Temporal trends and determinants of longitudinal change in 25-Hydroxyvitamin D and parathyroid hormone levels. Journal of Bone Mineral Research, 27(6):1381-1389.

Vitamin D is essential for facilitating calcium absorption and preventing increases in parathyroid hormone (PTH), which can augment bone resorption. Our objectives were to examine serum levels of 25-hydroxyvitamin D [25(OH)D] and PTH, and factors related to longitudinal change in a population-based cohort. This is the first longitudinal population-based study looking at PTH and 25(OH)D […]

Hitchcock CL, Prior JC. (2012) Oral Micronized Progesterone for Vasomotor Symptoms -a placebo-controlled randomized trial in healthy postmenopausal women. Menopause – The Journal of The North American Menopause Society,19(8) 866-93.

The aim of this study was to compare oral micronized progesterone (progesterone) with placebo as therapy for postmenopausal hot flushes and night sweats (vasomotor symptoms [VMS]). Healthy volunteer community women 1 to 10 years since final menstruation were recruited for a randomized double-blind placebo-controlled trial of progesterone (300 mg daily at bedtime) between 2003 and […]

Targownik LE, Leslie WD, Davison KS, Goltzman D, Jamal SA, Kreiger N, Josse RG, Kaiser SM, Kovacs CS, Prior JC, Zhou W; the CaMos Research Group (2012) The Relationship Between Proton Pump Inhibitor Use and Longitudinal Change in Bone Mineral Density: A Population-Based From the Canadian Multicentre Osteoporosis Study (CaMos). The American Journal of Gastroenteroogy. 107(9):1361-9.

Proton pump inhibitor (PPI) use has been identified as a risk factor for hip and vertebral fractures. Evidence supporting a relationship between PPI use and osteoporosis remains scant. Demonstrating that PPIs are associated with accelerated bone mineral density (BMD) loss would provide supportive evidence for a mechanism through which PPIs could increase fracture risk. We […]

Hitchcock CL, Elliot TG, Norman EG, Stajic V, Teede HJ and Prior JC (2012). Hot flushes and night sweats differ in associations with cardiovascular markers in healthy early postmenopausal women. Menopause – The Journal of The North American Menopause Society, 19(11):1208-14.

The aim of this study was to evaluate the associations between vasomotor symptoms ([VMS] hot flushes or flashes and night sweats) and markers of cardiovascular risk. Healthy postmenopausal women in a randomized controlled trial of progesterone for VMS recorded VMS frequency in the Daily Menopause Diary for 28 days at baseline. Accepted risks for cardiovascular […]

Prior JC, Hitchcock CL (2012) Progesterone for hot flush and night sweat treatment – effectiveness for severe vasomotor symptoms and lack of withdrawal rebound. Gynecological Endocrinology – the Journal of the International Society of Gynecological Endocrinology, 28 Suppl 2:7-11.

A controlled trial recently showed that oral micronized progesterone (Progesterone, 300 mg at h.s. daily) was effective for vasomotor symptoms (VMS) in 133 healthy early postmenopausal women. Here, we present subgroup data in women with severe VMS (50 VMS of moderate–severe intensity/wk) and also 1-mo withdrawal study outcomes. Women with severe VMS (n = 46) resembled […]

Koller DL, Zheng HF, Karasik D, Yerges-Armstrong L, Liu CT, McGuigan F, Kemp JP, Giroux S, Lai D, Edenberg HJ, Peacock M, Czerwinski SA, Choh AC, McMahon G, St Pourcain B, Timpson NJ, Lawlor DA, Evans DM, Towne B, Blangero J, Carless MA, Kammerer C, Goltzman D, Kovacs CS, Prior JC, Spector TD, Rousseau F, Tobias JH, Akesson K, Econs MJ, Mitchell BD, Richards JB, Kiel DP, Foroud T (2012). Meta-analysis of genome-wide studies identifies WNT16 and ESR1 SNPS associated with bone mineral density in premenopausal women. Journal of Bone Mineral Research, 28(3): 547-58.

Previous genome-wide association studies (GWAS) have identified common variants in genes associated with variation in bone mineral density (BMD), although most have been carried out in combined samples of older women and men. Meta-analyses of these results have identified numerous single-nucleotide polymorphisms (SNPs) of modest effect at genome-wide significance levels in genes involved in both […]

Poon C., Saewyc E., Chen, W. (2011). Enacted stigma, problem substance use, and protective factors among Asian sexual minority youth in British Columbia. Canadian Journal of Community Mental Health. 30(2), 47-64.

This study examined enacted stigma and problem substance use among Asian sexual minority youth and the buffering role of protective factors. Logistic regression analyses of a weighted sample of 5,423 Asian youth who completed the 2003 BC Adolescent Health Survey indicated that sexual minority youth were more likely to be victimized compared to heterosexual peers. […]

Kalyan, S., Hitchcock, C. L., Pudek, M., & Prior, J. C. (2011). Acute effects of premenopausal hysterectomy with bilateral oophorectomy on serum lipids, hormonal values, inflammatory markers and metabolism. Journal of Gynecologic Surgery, 27(1):9-15.

The aim of this study was to provide a clinical reference for the acute postoperative changes to lipids and inflammation following premenopausal hysterectomy with bilateral oophorectomy and compare them to normal reference values. The study design was a planned secondary analysis of data from a randomized double-blind trial comparing the effectiveness of two different hormone […]

Langsetmo L., Nguyen T.V., Nguyen N.D., Kovacs C.S, Prior J.C., Center J.R., Morin S., Josse R.G., Adachi J.D., Hanley D.A., Eisman J.A. and the CaMos Research Group (2011) Independent External Validation of Nomograms for Low Trauma Fracture and Hip Fracture Risk in a Population of Canadian Men and Women Ages 55-95. Canadian Medical Association Journal 183(2):E107-14.

A set of nomograms based on the Dubbo Osteoporosis Epidemiology Study predicts the five- and ten-year absolute risk of fracture using age, bone mineral density and history of falls and low-trauma fracture. We assessed the discrimination and calibration of these nomograms among participants in the Canadian Multicentre Osteoporosis Study. We included participants aged 55–95 years […]

Langsetmo L, Hanley DA, Prior JC, Barr SI, Anastassiades T, Towheed T ; CaMos Research Group (2011) Dietary patterns and incident low-trauma fractures in postmenopausal women and men aged ≥50 y: a population-based cohort study. American Journal of Clinical Nutrition 93(1):192-199.

Previous research has shown that dietary patterns are related to the risk of several adverse health outcomes, but the relation of these patterns to skeletal fragility is not well understood. Our objective was to determine the relation between dietary patterns and incident fracture and possible mediation of this relation by body mass index, bone mineral […]

Leslie WD, Kovacs CS, Olszynski WP, Towheed T, Kaiser SM, Prior JC, Josse RG, Jamal SA, Kreiger N, Goltzman D; CaMos Research Group (2011) Spine-Hip T-Score Difference Predicts Major Osteoporotic Fracture Risk Independent of FRAX(®): A Population-Based Report From CAMOS. Journal of Clinical Densitometry,14(3):286-93.

The WHO fracture risk assessment tool (FRAX®) estimates an individual’s 10-yr major osteoporotic and hip fracture probabilities. When bone mineral density (BMD) is included in the FRAX calculation, only the femoral neck measurement can be used. Recently, a procedure was reported for adjusting major osteoporotic fracture probability from FRAX with femoral neck BMD based on […]

Leslie WD, Berger C, Langsetmo L, Lix LM, Adachi JD, Hanley DA, Ioannidis G, Josse RG, Kovacs CS, Towheed T, Kaiser S, Olszynski WP, Prior JC, Jamal S, Kreiger N, Goltzman D; CaMos Research Group (2011) Construction and validation of a simplified fracture risk assessment tool for Canadian women and men: results from the CaMos and Manitoba cohorts. Osteoporosis International, 22(6):1873-83.

A procedure for creating a simplified version of fracture risk assessment tool (FRAX®) is described. Calibration, fracture prediction, and concordance were compared with the full FRAX tool using two large, complementary Canadian datasets. The Canadian Association of Radiologists and Osteoporosis Canada (CAROC) system for fracture risk assessment is based upon sex, age, bone mineral density […]

Prior JC (2011) Progesterone for Symptomatic Perimenopause Treatment – Progesterone politics, physiology and potential for perimenopause. Facts, Views and Vision in Obstetrics and Gynaecology, 3(2):109-120.

Perimenopause, women’s normal midlife reproductive transition, is highly symptomatic for about 20% of women who are currently inaccurately counseled and inappropriately treated with oral contraceptives, menopausal hormone therapy or hysterectomy. About 80% of perimenopausal women experience vasomotor symptoms (VMS), 25% have menorrhagia, and about 10% experience mastalgia. The majority of women describe varying intensities of […]

White CP, Hitchcock CL, Vigna YM and Prior JC (2011) Fluid Retention over the Menstrual Cycle: 1-Year Data from the Prospective Ovulation Cohort. Obstetrics and Gynecology International, vol. 2011 Article ID 138451.

We report menstrual and mid-cycle patterns of self-reported “fluid retention” in 765 menstrual cycles in 62 healthy women. Self-reported “fluid retention,” commonly described as bloating, is one element of the clinical assessment and diagnosis of premenstrual symptoms. These daily diary data were collected as part of an observational prospective one-year study of bone changes in […]

Kalyan S., Hitchcock C.L., Sirrs S., Pudek M., Prior J.C. (2010) Cardiovascular and metabolic effects of medroxyprogesterone acetate versus conjugated equine estrogen: A one-year randomized double-blind trial following premenopausal hysterectomy with bilateral ovariectomy. Pharmacotherapy. 2010; 30(5):442–452.

Study Objective: To compare the cardiovascular and metabolic effects of medroxyprogesterone acetate (MPA) with those of conjugated equine estrogen (CEE) as single-hormone therapies in women who underwent hysterectomy with bilateral ovariectomy. Design:  Secondary analysis of a 12–month, double-blind, randomized, parallel-therapy trial. Setting: Four teaching hospitals and one community hospital in Vancouver, Canada. Participants: Thirty-three healthy […]

Marks M., Hitchcock C.L., Sathi P., Prior J.C. (2010) Community pharmacists’ therapeutic recommendations for heavy flow, androgen excess, fragility fractures and night sweats in menstruating women. Canadian Pharmacist’s Journal 143;(2):88-95.e2.

Physicians and menstruating women often ask pharmacists for recommendations about menstrual cycle–related problems. Progesterone and medroxyprogesterone may provide physiology-based treatment, but official indications in menstruating women in Canada are minimal. To describe pharmacists’ responses to vignette-based questions about the treatment of common clinical problems in menstruating women and review evidence-based therapies.  A pharmacist interviewer administered […]

Battistella, E., Kalyan S., Prior J.C. (2010) Evaluation of successful methods and costs associated with recruiting 600 healthy women volunteers to a study of ovulation. Journal of Women’s Health. 19(8):1519-1524.

We address the crucial and challenging task of anticipating the resources needed to recruit eligible participants for research. We provide our analysis of various recruitment strategies and their cost-effectiveness in our experience in enrolling 610 women for an observational study on ovulation. We assess the cost-effectiveness and success of multiple recruitment strategies we employed and […]

Langsetmo L., Poliquin S., Hanley D.A., Prior J.C., Barr S., Anastassiades T., Towheed T., Goltzman D., Kreiger N. (2010) Dietary patterns in Canadian Men and Women Ages 25 and Older: Relationship to Demographics, Body Mass Index and Bone Mineral Density. BMC- Musculoskelet Disord; 11:20-26.

Previous research has shown that underlying dietary patterns are related to the risk of many different adverse health outcomes, but the relationship of these underlying patterns to skeletal fragility is not well understood. The objective of the study was to determine whether dietary patterns in men (ages 25-49, 50+) and women (pre-menopause, post-menopause) are related […]

Kingwell E, Prior J.C., Ratner P.A, Kennedy S.M., (2010) Direct-to-participant feedback and awareness of bone mineral density testing results in a population-based sample of mid-aged Canadians. Osteoporosis Int. 21(2):307-19.

This population-based study of mid-aged Canadians assessed awareness of diagnosis by bone mineral density (BMD) following dual-energy X-ray absorptiometry (DXA) testing and compared the effects of feedback only to the physician with direct-to-participant feedback. Poor recall of osteoporosis results was observed irrespective of the feedback destination, but direct-to-participant feedback improved recall of borderline or normal […]

Bedford J., Prior J.C., Barr S. (2010) A prospective exploration of cognitive dietary restraint, subclinical ovulatory disturbances, cortisol and change in bone density over two years in healthy young women. Journal of Clinical Endocrinology and Metabolism 95(7):3291-9.

Cross-sectional studies have found associations among elevated cognitive dietary restraint (CDR), increased ovulatory disturbances, and lower bone mass, possibly mediated by cortisol. To determine whether healthy young women with higher CDR have more menstrual cycles with subclinical ovulatory disturbances (SOD), elevated 24-h urinary free cortisol (UFC), and less positive 2-yr areal bone mineral density change […]

Zhou W., Langsetmo L., Berger C., Adachi J.D., Papaioannou A., Ioannidis G., Webber C., Atkinson S.A., Olszynski W.P., Brown J.P., Hanley D.A, Josse R., Kreiger N., Prior J.C, Kaiser S., Kirkland S., Goltzman D. and Davison K.S., the CaMos Research Group (2010) Normative bone mineral density Z-Scores for Canadians aged 16-24 yr: the Canadian Multicentre Osteoporosis Study Journal of Clinical Densitometry 13(3):267-7.

The objectives of the study were to develop bone mineral density (BMD) reference norms and BMD Z-scores at various skeletal sites, to determine whether prior fracture and/or asthma were related to BMD, and to assess possible geographic variation of BMD among Canadian youth aged 16–24 yr. Z-Scores were defined as the number of standard deviations […]

Berger C, Goltzman D, Langsetmo L, Joseph L, Jackson S, Kreiger N, Tenenhouse A, Davison KS, Josse RG, Prior JC, Hanley DA; CaMos Research Group (2010). Peak bone mass from longitudinal data: implications for the prevalence, pathophysiology, and diagnosis of osteoporosis. Journal of Bone Mineral Research, 25(9):1948-57.

We estimated peak bone mass (PBM) in 615 women and 527 men aged 16 to 40 years using longitudinal data from the Canadian Multicentre Osteoporosis Study (CaMos). Individual rates of change were averaged to find the mean rate of change for each baseline age. The age range for PBM was defined as the period during […]

Prior J.C., Hitchcock, C. L. (2010) The endocrinology of perimenopause: need for a paradigm shift. Frontiers in Bioscience (Schol Ed) 1 (3):474-86.

Perimenopause, rather than a time of declining estrogen, is characterized by three major hormonal changes that may begin in regularly menstruating women in their mid-thirties: erratically higher estradiol levels, decreased progesterone levels (in normally ovulatory, short luteal phase or anovulatory cycles), and disturbed ovarian-pituitary-hypothalamic feedback relationships. Recent data show that approximately a third of all […]

Langsetmo L, Leslie WD, Zhou W, Goltzman D, Kovacs CS, Prior J, Josse R, Olszynski WP, Davison KS, Anastassiades T, Towheed T, Hanley DA, Kaiser S, Kreiger N; CaMOS Research Group (2010) Using the same bone density reference database for men and women provides a simpler estimation of fracture risk. Journal of Bone Mineral Research 25(10):2108-14.

Although low bone mineral density (BMD) predicts fractures, there are postulated sex differences in the fracture “threshold.” Some studies demonstrate a higher mean BMD for men with fractures than for women, whereas others note similar absolute risk at the same level of BMD. Our objective was to test the preceding observations in the population-based Canadian […]

Langsetmo L, Morin S, Kovacs CS, Kreiger N, Josse R, Adachi JD, Papaioannou A, Goltzman D, Hanley DA, Olszynski WP, Prior J, Jamal SA; CaMos Research Group (2010) Determining whether women with osteopenic bone mineral density have low, moderate, or high clinical fracture risk. Menopause 17(5):1010-6.

Most low-trauma fractures occur among women with osteopenic bone mineral density (BMD), a population considered to have moderate absolute fracture risk. Our purpose was to refine the fracture risk prediction in women with osteopenic BMD to determine the subgroups at lowest and highest risk. We included 2,588 women aged 50 to 90 years with osteopenic […]

Kalyan S, Prior JC (2010) Bone Changes and Fracture Related to Menstrual Cycles and Ovulation. Critical Reviews of Eukaryotic Gene Expression 20(3):213-33.

Women’s menstrual cycles and bone remodeling are linked in part by their co-dependency on the stress- and resource-associated variables that govern both of their cyclical natures. Therefore, it is not surprising that evolution has resulted in the same signaling molecules and pathways that regulate normal ovarian function to be involved in bone remodeling and turnover. […]

Seifert-Klauss V and Prior J.C (2010) Progesterone and Bone – Actions Promoting Bone Health in Women. Journal of Osteoporosis Oct 31;2010:845180.

Estradiol ( E 2 ) and progesterone ( P 4 ) collaborate within bone remodelling on resorption ( E 2 ) and formation ( P 4 ). We integrate evidence that P 4 may prevent and, with antiresorptives, treat women’s osteoporosis. P 4 stimulates osteoblast differentiation in vitro. Menarche ( E 2 ) and onset […]

Certain H, Harahan B, Saewyc E, Fleming M. (2009). Condom use in heavy drinking college students: The importance of always using condoms. Journal of American College Health, 58(3), 187-194.

Objective: The authors examined whether alcohol use decreased condom use Participants: The subjects were heavy-drinking students on 5 different college campuses. Methods: A face-to-face interview, administered between November of 2004 and February of 2007, gathered information about condom use, alcohol use, and other behaviors. Multivariate logistic regression was used to assess predictors of condom use. […]

Berger, C., Langsetmo, L., Joseph, L., Hanley, D.A., Davison, S.K., Josse, R.G., Prior, J.C., Krieger, N., Tenenhouse, A., Goltzman, D., and the CaMos Research Group (2009). Association between change in BMD and fragility fracture in women and men. Journal of Bone Mineral Research, 24(2): 361-371.

Our objective was to estimate the relationship between longitudinal change in BMD and fragility fractures. We studied 3635 women and 1417 men 50–85 yr of age in the Canadian Multicentre Osteoporosis Study who had at least two BMD measurements (lumbar spine, femoral neck, total hip, and trochanter) within the first 5 yr of the study […]

Papaioannou A, Kennedy C.C., Ioanidis G., Sawka A., Hopman W.M., Pickard L., Brown J.P., Josse R.G., KaiserS., Anastassiades T., Goltzman., D Papadimirtopoulous M., Tenenhouse A., Prior J.C., Olszynski W.P., Adachi J.D., for the CaMos Research Group (2009). The impact of incident fractures on health-related quality of life: 5 years of data from the Canadian Multicentre Osteoporosis Study. Osteoporosis International, 20:703-714.

Using prospective data from the Canadian Multicentre Osteoporosis Study (CaMos), we compared health utilities index (HUI) scores after 5 years of follow-up among participants (50 years and older) with and without incident clinical fractures. Incident fractures had a negative impact on HUI scores over time. This study examined change in health-related quality of life (HRQL) […]

Jamal S.A, Goltzman D, Hanley D.A., Papaioannou D., Prior J.C., Josse R.G. (2009). Nitrate use and changes in bone mineral density: the Canadian Multicentre Osteoporosis Study. Osteoporosis International, 20, (5): 737-741.

Nitrates may have beneficial effects on bone. To determine if nitrates were associated with increased bone mineral density (BMD), we conducted a secondary analysis using data from subjects in a prospective study. Subjects reporting nitrate use had increased BMD compared with non-users, confirming that nitrates have positive BMD effects in women and men. Prior studies […]

Langsetmo L.A, Morin, S., Richards, J.B., Davison, K.S., Olszynski W.P, Prior, J.C., Josse, R., Goltzman, D., & CaMos Research Group (2009). Effectiveness of antiresorptives for the prevention of non-vertebral low-trauma fractures in a population-based cohort of women. Osteoporosis International, 20:283–290.

Observational studies are needed to quantify real-life effectiveness of antiresorptive therapy in the prevention of clinical fractures. Antiresorptive therapies were associated with an overall 32% reduction in low-trauma nonvertebral fracture risk among women 50 and older. Effectiveness may be lower among older women and those without risk factors. Randomized controlled trials have shown that antiresorptive […]

Chen P., Krege J.H., Adachi J.D., Prior J.C., Tenenhouse A., Brown J.P., Papadimitropoulos M., Kreiger N., Olszynski W.P., Josse R.G., Goltzman D. (2009). Vertebral Fracture Status and the World Health Organization (WHO) Risk Factors for Predicting Osteoporotic Fracture Risk. Journal of Bone Mineral Research, 24(3): 495-502.

Vertebral fractures are the most common osteoporotic fracture, and patients with prevalent vertebral fractures have a greater risk of future fractures. However, radiographically determined vertebral fractures are not identified as a distinct risk factor in the World Health Organization (WHO) fracture risk assessment tool. The objective of this study was to evaluate and compare potential […]

Harvey A.T., Hitchcock C.L., Prior J.C. (2009). Ovulation disturbances and mood across the menstrual cycles of healthy women. Journal of Psychosomatic Obstetrics and Gynecology, 30(4), 207-214.

We examined the cyclicity of negative mood relative to ovulation and ovulation disturbances in Menstrual Cycle Diary© data collected daily during a 1-year study of ovulation, exercise, and bone change. A validated quantitative basal temperature-based methodology was used to determine the onset of the luteal phase. ‘Feeling depressed’, ‘feeling anxious’, and ‘feeling angry/frustrated’ were scored […]

Ioannidis G., Papaioannou A., Hopman W.M., Akhatar-Danesh N., Anastassiades T., Pickard L., Kennedy C.C., Prior J.C., Olszynski W.P., Davison K.S., Goltzman D., Thabane L., Gafni A., Papadimitriopoulos E.A., Brown J.P., Josse R.G., Hanley D.A., Adachi J.D. (2009) Relationship between fractures and mortality: results from the Canadian Multicentre Osteoporosis Study. Canadian Medical Association Journal, 181: 265-271.

Fractures have largely been assessed by their impact on quality of life or health care costs. We conducted this study to evaluate the relation between fractures and mortality. A total of 7753 randomly selected people (2187 men and 5566 women) aged 50 years and older from across Canada participated in a 5-year observational cohort study. […]

Bedford J.L., Prior J.C., Hitchcock C.L., & Barr S.I. (2009). Detecting evidence of luteal activity by least squares quantitative basal temperature analysis against urinary progesterone metabolites and the effect of wake-time variability. European Journal of Obstetrics and Gynecology and Reproductive Biology, 146:76-80.

Objective: To assess computerised least-squares analysis of quantitative basal temperature (LS-BT) against urinary pregnanediol glucuronide (PdG) as an indirect measure of ovulation, and to evaluate the stability of LS-QBT to wake-time variation. Study design: Cross-sectional study of 40 healthy, normal-weight, regularly menstruating women aged 19–34. Participants recorded basal temperature and collected first void urine daily […]

Langsetmo L., Goltzman D., Kovacs C.S., Adachi J.D., Hanley D.A., Kreiger N., Josse R., Papaionnou A., Olszynski W.P., Jamal SA, CaMOS Research Group (2009). Repeat low-trauma fractures occur frequently among men and women who have osteopenic BMD. Journal of Bone and Mineral Research, (9):1515-22.

Fracture risk assessment based solely on BMD has limitations. Additional risk factors include the presence of a previous low-trauma fracture. We sought to quantify the fracture burden attributable to first versus repeat fracture. We studied 2179 men and 5269 women, 50–90 yr of age, participating in the Canadian Multicentre Osteoporosis Study (CaMos). We included all […]

Jamal S.A., Swan V.J., Brown J.P., Hanley D.A., Prior J.C., Papaioannou A., Langsetmo L., Josse R.G., Canadian Multicentre Osteoporosis Study Research Group. (2009) Kidney Function and Rate of Bone Loss at the Hip and Spine: The Canadian Multicentre Osteoporosis Study. American Journal of Kidney Function, 55(2):291-299.

Background: The relationship between kidney function and bone loss is unclear. Study Design: A prospective observational study. Setting & Participants: 191 men and 444 women aged ≥50 years participating in a population-based observational study designed to determine risk factors for bone loss and fractures. Predictors: The primary predictor of change in bone mineral density (BMD) […]

Hopman WM, Berger C, Joseph L, Towheed T, Prior JC, Anastassiades T, Poliquin S, Zhou W, Adachi JD, Hanley DA, Papadimitropoulos EA, Tenenhouse A, CaMos Research Group (2009). Health-related quality of life in Canadian adolescents and young adults: Normative data using the SF-3. Canadian Journal of Public Health, 100:449-52.

Normative data for the SF-36 measure of health-related quality of life (HRQOL) exist for those over 25 years of age, based on data from the population-based Canadian Multicentre Osteoporosis Study (CaMos). CaMos recently recruited a sample of young Canadians aged between 16 and 24 years. The purpose of this study was to develop normative SF-36 […]

Berger, C., Langsetmo, L., Joseph, L., Hanley, D.A., Davison, K.S., Josse, R., Krieger, N., Tenenhouse, A., Goltzman, D., & CaMos Research Group. (2008). Change in bone mineral density as a function of age in women and men and association with the use of antiresorptive agents. Canadian Medical Association Journal, 178(13): 1660-8.

Measurement of bone mineral density is the most common method of diagnosing and assessing osteoporosis. We sought to estimate the average rate of change in bone mineral density as a function of age among Canadians aged 25–85, stratified by sex and use of antiresorptive agents. We examined a longitudinal cohort of 9423 participants. We measured […]

Papaioannou, A., Kennedy, C.C., Ioannidis, G., Gao, Y., Sawka, A.M., Goltzman, D., Tenenhouse, A., Pickard, L., Olszynski, W.P., Davison, K.S., Kaiser, S., Josse, R.G., Kreiger, N., Hanley, D.A., Prior, J.C., Brown, J.P., Anastassiades, T., Adachi, J.D., & CaMos Research Group. (2008). The osteoporosis care gap in men with fragility fractures: The Canadian Multicentre Osteoporosis Study. Osteoporosis International, 19(4): 581-587.

We examined osteoporosis diagnosis/treatment in 2,187 community dwelling men age 50+. After five years in the study, 90% of men with fragility fractures remained undiagnosed and untreated for osteoporosis. The need to treat fragility fractures is well established in guidelines, and these numbers represent an important care gap. Whether physicians in the community are recognizing […]

Langsetmo, L., Hanley, D.A., Kreiger, N., Jamal, S.A., Prior, J.C., Adachi, J.D., Davison, K.S., Kovacs, C., Anastassiades, T., Tenenhouse, A., Goltzman, D., & CaMos Research Group. (2008). Geographic variation of bone mineral density and selected risk factors for prediction of incident fracture among Canadians 50 and older. Bone, 43 (4): 672-678.

Background: Striking geographic variation in the incidence of osteoporotic fracture has been shown in national and international studies. The contributing risk factors for this variation are not fully understood. Objective: To determine the geographic variation of bone mineral density (BMD) values, prevalent low-trauma fracture, prior falls, and vertebral deformity and to determine how this variation […]

Harris A., Prior J.C., Koehoorn M. (2008). Age at menarche in the Canadian population: secular trends and relationship to adulthood BMI. Journal of Adolescent Health, 43:548–554.

Studies from around the world indicate a trend toward younger ages of menarche. The extent of this trend in the Canadian population is unknown, and the relationship to later-life health indicators has not yet been fully elucidated. The objective of this study is to estimate the trend in age at menarche (AAM) in the Canadian […]

Homma Y, & Saewyc EM. (2007). The emotional well-being of Asian-American sexual minority youth in school. Journal of LGBT Health Research, 3(1), 67-78.

This study examined family and school correlates of emotional distress among Asian-American sexual minority youth in the Midwestern United States. Responses from 91 predominantly Hmong Asian-American youth who participated in a state-wide, school-based census survey and reported recent same-gender sexual activity were analyzed. Results showed that sexual minority youth who perceived lower levels of family […]

Garcia CM & Saewyc EM. (2007). Perceptions of mental health among recently-immigrated Mexican adolescents. Issues in Mental Health Nursing, 28(1), 37-54.

Rates of anxiety, depression, and suicidal ideation are high among Latino adolescents in the U.S., many of whom are immigrants. Immigration during adolescence creates risk factors for mental health problems. The purpose of this study was to explore the health-related perceptions of Mexican-origin immigrant adolescents to inform the design of culturally and developmentally appropriate mental […]

Garcia CM, Duckett LJ, Saewyc EM, Bearinger LH. (2007). Perceptions of Health among Immigrant Latino Adolescents from Mexico. Journal of Holistic Nursing, 25, 81-91.

Purpose: This ethnographic study describes the health-related perceptions of immigrant Latino adolescents from Mexico. Method: Fourteen adolescents, purposively recruited from two non-health-based community settings, participated. Each was interviewed twice and completed a visual narrative project using disposable cameras. Audiotaped transcripts and photographs were inductively analyzed. Findings: Being healthy is holistically perceived by these adolescents and […]

Saewyc EM, Skay CL, Hynds P, Pettingell S, Bearinger LH, Resnick MD, Reis E. (2007). Suicidal ideation and attempts among adolescents in North American school-based surveys: Are bisexual youth at increasing risk? Journal of LGBT Health Research, 3(2), 25-36.

This study explored the prevalence, disparity, and cohort trends in suicidality among bisexual teens vs. heterosexual and gay/lesbian peers in 9 population-based high school surveys in Canada and the U.S. Multivariate logistic regressions were used to calculate age-adjusted odds ratios separately by gender; 95% confidence intervals tested cohort trends where surveys were repeated over multiple […]

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